Antimicrobial Resistance Conferred by OXA-48 ?-Lactamases: Towards a Detailed Mechanistic Understanding
نویسندگان
چکیده
OXA-48-type ?-lactamases are now routinely encountered in bacterial infections caused by carbapenem-resistant Enterobacterales . These enzymes of high and growing clinical significance due to the importance carbapenems treatment health care-associated Gram-negative bacteria, wide increasing dissemination OXA-48 on plasmids, challenges posed their detection.
منابع مشابه
Heterogeneous hydrolytic features for OXA-48-like β-lactamases.
OBJECTIVES Carbapenem-hydrolysing class D β-lactamases of the OXA-48 type are increasingly reported from Enterobacteriaceae. β-Lactamase OXA-48 hydrolyses penicillins very efficiently, but carbapenems only weakly and spares broad-spectrum cephalosporins. Recently, diverse OXA-48-like β-lactamases have been identified worldwide (OXA-162, OXA-181, OXA-163, OXA-204 and OXA-232). They differ by few...
متن کاملHeterogeneous hydrolytic features for OXA-48-like b-lactamases
INSERM U914 ‘Emerging Resistance to Antibiotics’, K.-Bicêtre, France; LabEx LERMIT, Faculté de Médecine Paris Sud, K.-Bicêtre, France; Centre National Associé-Centre de Référence des Résistances aux Antibiotiques, K.-Bicêtre, France; Medical and Molecular Microbiology, Department of Medicine, Faculty of Science, University of Fribourg, Fribourg, Switzerland; HFR-Hôpital Cantonal, Fribourg, Swit...
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Based upon knowledge of the hydrolytic profile of major β-lactamases found in Gram-negative bacteria, we tested the efficacy of the combination of ceftazidime-avibactam (CAZ-AVI) with aztreonam (ATM) against carbapenem-resistant enteric bacteria possessing metallo-β-lactamases (MBLs). Disk diffusion and agar-based antimicrobial susceptibility testing were initially performed to determine the in...
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Multi-drug resistance (MDR) has become a serious clinical problem for both cancer and infectious disease treatment. One of the leading causes of MDR is the drug efflux mediated by the ATP-binding cassette (ABC) super-family of proteins which are found among diverse groups of organisms. In our laboratory, we are interested in studying an ABC transporter DrrAB from Streptomyces peucetius. It conf...
متن کاملComparative evaluation of a novel chromogenic medium (chromID OXA-48) for detection of OXA-48 producing Enterobacteriaceae.
Comparative evaluation of the recently developed chromogenic culture medium chromID OXA-48 (bioMérieux) with chromID CARBA (bioMérieux) and SUPERCARBA showed that chromID OXA-48 and SUPERCARBA media have the highest sensitivity for detection of OXA-48 producing Enterobacteriaceae (91% and 93%) comparatively to chromID CARBA (21 %). The chromID OXA-48 has the highest specificity, with 100%, as c...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2021
ISSN: ['0066-4804', '1070-6283', '1098-6596']
DOI: https://doi.org/10.1128/aac.00184-21